ncRNA name | Gucy2e shRNA |
ncRNA Category | shRNA |
Disease name | retinitis pigmentosa (RP) |
Species | Mus musculus |
Tissues/Cell_line | retinas |
Methods | H&E staining, immunoblot, shRNA knockdown, ERG |
Expression pattern | associated |
Functional description | Gucy2e- or Cnga1-shRNA lentiviral-mediated knockdown GUCY2E and CNGA1 expression increase visual function and photoreceptor survival in Pde6b(H620Q) mice. |
PubMed ID | 20950332 |
Year | 2011 |
Title | shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa. |
Drug-related ncRNA | NA |
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