logo

        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinitis pigmentosa (RP)
ncRNA name Gucy2e shRNA
ncRNA Category shRNA
Disease name retinitis pigmentosa (RP)
Species Mus musculus
Tissues/Cell_line retinas
Methods H&E staining, immunoblot, shRNA knockdown, ERG
Expression pattern associated
Functional description Gucy2e- or Cnga1-shRNA lentiviral-mediated knockdown GUCY2E and CNGA1 expression increase visual function and photoreceptor survival in Pde6b(H620Q) mice.
PubMed ID 20950332
Year 2011
Title shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa.
Drug-related ncRNA NA

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.